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A novel contraceptive approach for men involving a gel applied to the shoulders has been found to be safe, effective, and to act more swiftly in reducing sperm count than existing options, as indicated by recent study outcomes.
On average, the gel brought men’s sperm levels down to a contraceptive-effective threshold within just eight weeks, a notable improvement over the nine to 15 weeks required for male contraceptive injections to take effect.
Researchers from the NIH’s Contraceptive Development Programme suggest the new method may be more appealing to men due to its faster action.
In the study, 222 male participants used the gel daily, applying 5ml – roughly a teaspoon – to each of their shoulder blades.
Comprising testosterone and a synthetic hormone named Nestorone, the gel formulation acts to diminish sperm count. Whereas testosterone alone can achieve this effect, the inclusion of Nestorone accelerates the process and allows for a lower testosterone dosage, minimizing impacts on libido and reducing other potential side effects.
While still under investigation, this gel is at the forefront of a wave of advanced male contraceptive solutions.
One trial participant, Logan Whitehead, 24, conveyed to Sky News’s US affiliate NBC News that he would be inclined to continue using the gel if it were made widely available, especially after witnessing the difficulties his partner faced with female contraceptive options.
Whitehead mentioned that the gel application was straightforward—akin to a daily pill—and encountered minimal side effects, such as a slight increase in back acne and perhaps minor weight gain, which could relate to a change in his job’s physical demands.
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The study’s researchers are now delving further into the contraceptive efficacy of the gel, its safety profile, user satisfaction, and the duration needed for its effects to be reversible post-treatment.
However, financial backing for phase three trials, a critical next step for drug approval, is currently lacking.
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Dr Brian Nguyen, a gynecologist and investigator in the gel study, expressed to NBC News the necessity of major pharmaceutical sponsorship to advance the research.
He acknowledged the reality that many couples still rely on female contraceptives, despite men demonstrating an interest in more options.
“That doesn’t mean they’re content with them or wouldn’t welcome a male alternative,” he added.
“People often inquire about the timeline for this product reaching the market,” Dr Nguyen stated.
“The usual estimate is five to 10 years, but I am less cynical.”
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FAQ – Male Contraceptive Gel
- How does the male contraceptive gel work?
The gel combines two hormones—testosterone and Nestorone—to decrease sperm count. Nestorone accelerates the reduction process allowing for lower amounts of testosterone to be used, minimizing potential side effects. - How is the gel applied?
Men apply approximately 5ml of the gel to their shoulder blades each day, using a simple, non-invasive method similar to applying lotion. - How quickly does the male contraceptive gel take effect?
The gel reduces sperm count to effective contraceptive levels within an average of eight weeks, which is faster than hormonal injections for men. - What are the side effects of the male contraceptive gel?
Some men have reported minor side effects such as increased back acne or slight weight gain, which could also be attributed to lifestyle changes. - Is the male contraceptive gel available on the market?
No, the male contraceptive gel is still in the trial phase and is not yet available to the public. Further research and funding are needed to bring it to market. - Are there other male contraceptive options in development?
Yes, there are various male contraceptive methods being researched, including pills and gels, which aim to provide reversible and non-permanent options for men.
